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Central administration of palmitoylethanolamide lessens hyperalgesia in mice by means of inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J Pharmacol1996). Oral PEA also lessened paw oedema induced by carrageenan, dextran and formalin, suggesting the compound immediately down‐modulates mast mobile activation in vivoNone of th